Edgar F. Ferrer-González, Ph.D.

Mechanistic Scientist building translational platforms for antimicrobial, microbiome, and infection-control innovation

Selected Work

This work represents an ongoing, industry-based platform designed to address biofilm persistence using non-corrosive, mechanism-aware strategies suitable for repeated use and consumer-facing environments. Rather than optimizing for maximal destruction, the platform focuses on controlled interference with biofilm formation, maturation, and maintenance—balancing efficacy, safety, and real-world usability.

I build analysis workflows that make complex microbiology interpretable and comparable across experiments, operators, and partners. The focus is not “pretty plots”—it’s turning heterogeneous biological readouts (growth/kill, microscopy-derived phenotypes, functional profiling, and multi-factor assay panels) into quality-controlled evidence that supports go/no-go decisions, mechanistic interpretation, and cross-functional alignment.

I build mechanism-first antibacterial platforms around the bacterial division machinery (FtsZ) to turn “synergy” into decision-grade evidence. The work connects three layers: (1) chemical tools that visualize or perturb FtsZ in live cells, (2) experiments that explain how division disruption re-wires cell-wall synthesis and PBP organization, and (3) translational combination studies showing that FtsZ inhibition can potentiate β-lactams (including oxacillin) against MRSA.

About Me

Edgar F. Ferrer-Gonzalez

Illuminating the invisible machinery of life to engineer better interventions.

I was drawn early to biomedical research and healthcare, guided by the realization that the greatest leverage lies not in treating symptoms, but in understanding and redesigning the systems that generate them. That systems-thinking lens, shaped by genetics and microbial physiology, has since defined my work at the intersection of antimicrobial resistance (AMR), host–microbe interactions, and experimental therapeutics.

I specialize in uncovering and operationalizing the mechanisms that govern microbial behavior. Early in my training, visualizing mCherry-tagged proteins inside living bacteria made something clear to me: seeing the mechanism is the first step toward controlling it. Since then, my work has focused on making invisible biological processes legible, measurable, and actionable whether through molecular tools, assay platforms, or data-driven experimental models.

Today, I work as an industry scientist developing and scaling experimental systems that support antimicrobial, microbiome, and biofilm-focused innovation. I lead the design and execution of studies across internal labs and CRO partnerships, build regulatory-aligned assay platforms, and translate complex biological outputs into decision-grade evidence that informs pipeline strategy, product development, and claims substantiation.

A core throughline of my work is platform thinking: building tools, workflows, and models that outlive individual projects and enable faster, more confident decisions across teams. This includes co-inventing imaging technologies licensed by MilliporeSigma, establishing antimicrobial and anti-biofilm testing pipelines, and integrating experimental data with clear scientific narratives for cross-functional stakeholders.

I am driven by the challenge of antimicrobial resistance and by the belief that durable solutions emerge when scientific depth is paired with systems-level thinking and strong execution. My goal is to lead platforms and programs that transform complex microbiology into strategic advantage advancing therapeutics, informing innovation, and ultimately improving health outcomes at scale.

LEADERSHIP STYLE

Strategic Orchestration:I lead by establishing the technical "gold standards" in the lab, then empowering teams to execute within scalable frameworks that ensure scientific rigor and independence.

SCIENTIFIC MISSION

The Engine of Discovery: I don’t just interpret data; I architect the experimental platforms and quantitative workflows that generate the high-fidelity evidence models cannot yet predict.

Publications & Patents

Fluorescent probes for the visualization of FtsZ in Gram-positive and Gram-negative bacterial pathogens

U.S. Patent 12,061,201 B2 • 2024

Novel fluorescent probes designed to target the FtsZ protein for real-time visualization of division machinery. Licensed and commercialized via MilliporeSigma.

Taxonomic and functional profiling of the vulvar microbiome indicates variations related to ecological signatures, aging, and health status

Frontiers in Microbiology • 2025

This study utilizes taxonomic and functional profiling to characterize the vulvar microbiome across different life stages. It identifies specific ecological signatures and microbial variations that correlate with aging and overall health status.

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against MRSA

Medicinal Chemistry Research • 2022

Demonstrates how FtsZ inhibitors restore effectiveness of traditional antibiotics like oxacillin against MRSA strains.

Novel MreB inhibitors with antibacterial activity against Gram-negative bacteria

Medicinal Chemistry Research • 2022

Identification of small molecules that inhibit MreB, targeting the bacterial cytoskeleton in Gram-negative pathogens.

Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor

ACS Chemical Biology • 2022

Discovery of a new benzamide compound with superior bactericidal activity and in vivo efficacy against multidrug-resistant MRSA.

Impact of FtsZ inhibition on the localization of penicillin binding proteins in MRSA

Journal of Bacteriology • 2021

Investigation of the spatial relationship between FtsZ and penicillin-binding proteins in MRSA cell wall synthesis.

Structure-guided design of a fluorescent probe for the visualization of FtsZ

Scientific Reports • 2019

Structure-guided molecular design of versatile fluorescent probes for FtsZ protein across clinical pathogens.

β-Lactam antibiotics with high affinity for PBP2 act synergistically with FtsZ-targeting agent TXA707

Antimicrobial Agents and Chemotherapy • 2017

Identifies beta-lactams with high PBP2 affinity that maximize synergy with FtsZ inhibitors against MRSA.

Blog & Writing

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Research Platforms & Strategic Focus

Platform ownership examples illustrating transferable systems-level expertise.

01 // Platform

AMR & Infection
Control Platforms

Designing mechanistic and translational platforms to combat antimicrobial resistance by breaking persistence, transmission, and treatment failure across clinical and consumer environments.

02 // Systems

Biofilm &
Microbial Systems

Understanding and disrupting microbial systems—biofilms, communities, and host–microbe interactions—to reduce chronic infection risk and improve intervention durability.

03 // Translation

Mechanistic
Pharmacology

Translating molecular and cellular mechanisms into decision-grade evidence that informs therapeutic strategy, candidate selection, and resistance-mitigation approaches.

04 // Enablement

Scientific Platforms &
Decision Enablement

Building scalable assay systems, analytics, and scientific narratives that turn complex biological data into confident decisions across R&D, regulatory, and product teams.